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Protein structure
TRAF1
TNF receptor associated factor 1EBI6
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Top validated antibodies |
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| Proteintech Group |  26845-1-AP |
5 references | Polyclonal |
EL
ICC
IHC
FC
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| Invitrogen Antibodies | MA5-15043 |
1 references | Monoclonal |
WB
ICC
IP
IHC
FC
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| Novus Biologicals | NB100-2822 |
2 references | Polyclonal |
WB
EL
IHC
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| Cell Signaling Technology, Inc | 4715 |
Monoclonal |
WB
ICC
IP
IHC
FC
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| antibodies-online | ABIN251285 |
2 references | Polyclonal |
WB
EL
ICC
IHC
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