SIRT6

This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Description

sirtuin 6

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

19:p13.3 (4174109 - 4182566)

Ensembl ID

ENSG00000077463  (ver. 99.38)

Orthologs

Mouse Sirt6: ENSMUSG00000034748

UniProt

Q8N6T7

neXtProt

NX_Q8N6T7

Human splice variants
Mouse splice variants