HIF3A

The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]

Description

hypoxia inducible factor 3 subunit alpha

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Transcription factors

Chromosome

19:q13.32 (46297046 - 46343433)

Ensembl ID

ENSG00000124440  (ver. 99.38)

Orthologs

Mouse Hif3a: ENSMUSG00000004328

UniProt

Q9Y2N7

neXtProt

NX_Q9Y2N7

Human splice variants
Mouse splice variants