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APOA1
Apolipoprotein A1This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]
Top validated antibodies |
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| Invitrogen Antibodies |  MIA1402 |
2 references | Monoclonal |
WB
EL
ICC
IHC
FC
OA
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| Proteintech Group | 14427-1-AP |
21 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Novus Biologicals | NB600-609 |
8 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| LSBio | LS-C355402 |
Monoclonal |
WB
EL
ICC
IHC
RA
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| OriGene | R1029P |
1 references | Polyclonal |
WB
EL
IP
IHC
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