TNFSF11

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]

Description

TNF superfamily member 11

Tissue specificity

Tissue enhanced (breast, liver, lymphoid tissue)

Predicted location

Intracellular, Membrane, Secreted to blood

Protein family

Cancer-related genes
CD markers
Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Chromosome

13 (42562736 - 42608013)

Ensembl ID

ENSG00000120659  (ver. 103.38)

Orthologs

Mouse Tnfsf11: ENSMUSG00000022015

UniProt

O14788

neXtProt

NX_O14788

Human splice variants
Mouse splice variants

Protein structure