PTPN13

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]

Description

Protein tyrosine phosphatase non-receptor type 13

Tissue specificity

Tissue enhanced (retina)

Subcell location

Nucleoplasm, Nucleoli fibrillar center, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (86594315 - 86815171)

Ensembl ID

ENSG00000163629  (ver. 103.38)

Orthologs

Mouse Ptpn13: ENSMUSG00000034573

UniProt

Q12923

neXtProt

NX_Q12923

Human splice variants
Mouse splice variants

Protein structure