FGFR4

The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]

Description

Fibroblast growth factor receptor 4

Tissue specificity

Tissue enhanced (liver, lung)

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
CD markers
Disease related genes
Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
RAS pathway related proteins
Transporters

Chromosome

5 (177086905 - 177098144)

Ensembl ID

ENSG00000160867  (ver. 103.38)

Orthologs

Mouse Fgfr4: ENSMUSG00000005320

UniProt

P22455

neXtProt

NX_P22455

Human splice variants
Mouse splice variants

Protein structure