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Protein structure
TTK
TTK protein kinaseCT96, MPH1, MPS1, MPS1L1
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Top validated antibodies |
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| Proteintech Group |  10381-1-AP |
5 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Invitrogen Antibodies | 35-9100 |
4 references | Monoclonal |
WB
EL
ICC
IP
OA
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| NSJ Bioreagents | RQ6076 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Novus Biologicals | H00007272-M02 |
4 references | Monoclonal |
WB
EL
ICC
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| Boster Biological Technology | A01132-1 |
Polyclonal |
WB
EL
ICC
IHC
FC
|
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