Tissue expression
Cell line expression
Protein structure
PRKCI
Protein kinase C iotaDXS1179E, PKCI
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Proteintech Group | 13883-1-AP | 7 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
|
Invitrogen Antibodies | 13883-1-AP | Polyclonal |
WB
ICC
IP
IHC
FC
OA |
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Novus Biologicals | H00005584-M01 | 1 references | Monoclonal |
WB
EL
ICC
BN |
|
GeneTex | GTX25813 | 4 references | Polyclonal |
WB
ICC
FC
|
|
LSBio | LS-C197989 | Monoclonal |
WB
EL
ICC
|
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Supportive data in Antibodypedia
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