SIGLEC5

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]

Description

Sialic acid binding Ig like lectin 5

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Predicted location

Membrane

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (51611927 - 51645545)

Ensembl ID

ENSG00000105501  (ver. 103.38)

Orthologs

-

UniProt

O15389

neXtProt

NX_O15389

Human splice variants

Protein structure