CKAP5

This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Description

Cytoskeleton associated protein 5

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli, Nucleoli rim, Plasma membrane, Centrosome

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (46743048 - 46846308)

Ensembl ID

ENSG00000175216  (ver. 103.38)

Orthologs

Mouse Ckap5: ENSMUSG00000040549

UniProt

Q14008

neXtProt

NX_Q14008

Human splice variants
Mouse splice variants

Protein structure