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LearnTissue expression
Cell line expression
Protein structure
PDGFRB
Platelet derived growth factor receptor betaCD140b, JTK12, PDGFR, PDGFR1
The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017]
Top validated antibodies |
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| Invitrogen Antibodies |  MA5-15143 |
8 references | Monoclonal |
WB
ICC
IP
IHC
OA
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| Novus Biologicals | AF385 |
21 references | Polyclonal |
WB
IHC
FC
BN
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| R&D Systems | AF385 |
19 references | Polyclonal |
WB
IHC
FC
BN
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| GeneTex | GTX10848 |
1 references | Polyclonal |
WB
EL
IHC
FC
BN
|
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| antibodies-online | ABIN2869531 |
3 references | Monoclonal |
WB
EL
FC
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