EIF4EBP1

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

Description

Eukaryotic translation initiation factor 4E binding protein 1

Tissue specificity

Tissue enhanced (pancreas, salivary gland)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8 (38030534 - 38060365)

Ensembl ID

ENSG00000187840  (ver. 103.38)

Orthologs

Mouse Eif4ebp1: ENSMUSG00000031490

UniProt

Q13541

neXtProt

NX_Q13541

Human splice variants
Mouse splice variants

Protein structure