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TGFB3
Transforming growth factor beta 3ARVD, ARVD1
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016]
Top validated antibodies |
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| Proteintech Group |  18942-1-AP |
12 references | Polyclonal |
WB
EL
IHC
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| R&D Systems | AF-243-NA |
4 references | Polyclonal |
WB
IHC
BN
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| Novus Biologicals | AF-243-NA |
4 references | Polyclonal |
WB
IHC
BN
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| antibodies-online | ABIN2029994 |
Polyclonal |
WB
EL
IHC
FC
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| Santa Cruz Biotechnology | sc-83 |
3 references | Polyclonal (Antigen purified) |
WB
IHC
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