ARHGDIB

Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]). [supplied by OMIM, Dec 2010]

Description

Rho GDP dissociation inhibitor beta

Tissue specificity

Group enriched (bone marrow, lymphoid tissue)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (14942031 - 14961728)

Ensembl ID

ENSG00000111348  (ver. 103.38)

Orthologs

Mouse Arhgdib: ENSMUSG00000030220

UniProt

P52566

neXtProt

NX_P52566

Human splice variants
Mouse splice variants

Protein structure