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TNF
Tumor necrosis factorDIF, TNF-alpha, TNFA, TNFSF2
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020]
Top validated antibodies |
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| R&D Systems |  AF-410-NA |
70 references | Polyclonal |
WB
EL
ICC
FC
BN
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| Novus Biologicals | AF-410-NA |
76 references | Polyclonal |
WB
ICC
IHC
FC
BN
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| Invitrogen Antibodies | PA5-46945 |
2 references | Polyclonal |
WB
EL
ICC
IHC
FC
BN
OA
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| Proteintech Group | 60291-1-Ig |
435 references | Monoclonal |
WB
EL
ICC
IHC
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| Boster Biological Technology | A00002-5 |
28 references | Polyclonal |
WB
EL
ICC
FC
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