TNF

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]

Description

tumor necrosis factor

Protein family

Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Protein evidence (Peptideatlas)

Chromosome

6:p21.33 (31575565 - 31578336)

Ensembl ID

ENSG00000232810  (ver. 99.38)

Orthologs

Mouse Tnf: ENSMUSG00000024401

UniProt

P01375

neXtProt

NX_P01375

Human splice variants
Mouse splice variants