PTPN11

gene product
BPTP3, NS1, PTP2C, SH-PTP2, SHP-2, SHP2
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
1398 antibodies from 45 providers.

Antibody properties

General

Applications

or Cancel
Antibody
antibodies-online
504 antibodies
Proteintech Group
5 antibodies
Novus Biologicals
42 antibodies
GeneTex
19 antibodies
Invitrogen Antibodies
32 antibodies
Boster Biological Technology
8 antibodies
Biorbyt
73 antibodies
NovoPro Bioscience Inc.
14 antibodies
Santa Cruz Biotechnology
1 antibody
Abnova Corporation
17 antibodies
LifeSpan BioSciences, Inc.
151 antibodies
Affinity Biosciences
8 antibodies
OriGene
43 antibodies
Acris Antibodies GmbH
34 antibodies
Arigo
8 antibodies
Signalway Antibody LLC
4 antibodies
NSJ Bioreagents
7 antibodies
Abgent
14 antibodies
Cell Signaling Technology, Inc
6 antibodies
R&D Systems
3 antibodies
Aviva Systems Biology
20 antibodies
ProSci
7 antibodies
St John's Laboratory
11 antibodies
Antibodies.com
1 antibody
Everest Biotech
1 antibody
Bioworld Technology, Inc
6 antibodies
Rockland Immunochemicals, Inc.
2 antibodies
SignalChem
3 antibodies
Bethyl Laboratories
1 antibody
Abbkine Scientific Co.Ltd.
5 antibodies
Creative Biolabs
27 antibodies
RabMAbs
10 antibodies
Creative Diagnostics
17 antibodies
MyBioSource
21 antibodies
Leading Biology
15 antibodies
Abbiotec
3 antibodies
United States Biological
170 antibodies
Spring Bioscience
4 antibodies
RayBiotech, Inc.
4 antibodies
Abiocode, Inc.
1 antibody
GenWay
8 antibodies
EMD Millipore
1 antibody
Sigma-Aldrich
8 antibodies
Abbexa
3 antibodies