Tissue expression
Cell line expression
Protein structure
TRIM5
Tripartite motif containing 5RNF88, TRIM5alpha
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]
Top validated antibodies |
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| Novus Biologicals | 1 references | Polyclonal |
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| LSBio | Polyclonal |
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| antibodies-online | 4 references | Polyclonal |
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| Boster Biological Technology | Polyclonal |
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| Cusabio Biotech Co., Ltd | 1 references | Polyclonal |
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