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Cell line expression
Protein structure
CTNNB1
Catenin beta 1armadillo, beta-catenin, CTNNB
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Top validated antibodies |
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| GeneTex |  GTX101435 |
21 references | Polyclonal |
WB
ICC
IP
IHC
FC
ChIP
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| Novus Biologicals | NBP1-32239 |
4 references | Polyclonal |
WB
ICC
IP
IHC
FC
PLA
ChIP
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| Invitrogen Antibodies | 13-8400 |
148 references | Monoclonal |
WB
ICC
IP
IHC
FC
OA
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| Proteintech Group | 51067-2-AP |
381 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| R&D Systems | AF1329 |
15 references | Polyclonal |
WB
ICC
IHC
FC
ChIP
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