CDKN2A

gene product
ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, p16INK4a, p19, p19Arf
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
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1404 antibodies from 51 providers.

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Novus Biologicals
84 antibodies
Proteintech Group
1 antibody
GeneTex
18 antibodies
Invitrogen Antibodies
27 antibodies
Abnova Corporation
44 antibodies
NovoPro Bioscience Inc.
7 antibodies
Biorbyt
115 antibodies
OriGene
163 antibodies
Abgent
22 antibodies
NSJ Bioreagents
13 antibodies
LifeSpan BioSciences, Inc.
370 antibodies
Boster Biological Technology
5 antibodies
St John's Laboratory
12 antibodies
Bethyl Laboratories
4 antibodies
Aviva Systems Biology
14 antibodies
R&D Systems
1 antibody
Affinity Biosciences
7 antibodies
Cell Signaling Technology, Inc
6 antibodies
Bioworld Technology, Inc
3 antibodies
Rockland Immunochemicals, Inc.
3 antibodies
Progen Biotechnik GmbH
2 antibodies
SignalChem
1 antibody
ProSci
9 antibodies
Antibodies.com
3 antibodies
Santa Cruz Biotechnology
1 antibody
RabMAbs
7 antibodies
Abbiotec
7 antibodies
BioLegend
1 antibody
PeproTech Inc.
6 antibodies
Abbkine Scientific Co.Ltd.
4 antibodies
Creative Diagnostics
9 antibodies
FabGennix
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Abbexa
5 antibodies
Creative Biolabs
63 antibodies
Everest Biotech
2 antibodies
MyBioSource
36 antibodies
RayBiotech, Inc.
5 antibodies
United States Biological
186 antibodies
Arigo
6 antibodies
Leading Biology
19 antibodies
GenWay
9 antibodies
EMD Millipore
5 antibodies
Sigma-Aldrich
6 antibodies
Atlas Antibodies
1 antibody
Miltenyi Biotec
6 antibodies
Spring Bioscience
4 antibodies
Abiocode, Inc.
1 antibody
DB Biotech
1 antibody
Exalpha Biologicals, Inc.
1 antibody
ONCOdianova
1 antibody